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Launch of rhBMP2 in India – Excerpts from Interview with rhBMP2 reconstruction pioneers

21/11/2013

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The launch of rhBMP2 in the Indian subcontinent was done in 2008. The rhBMP2 is a unique protein that helps to stimulate the latent osteocytes to get activated and produce bone. The rhBMP2 also attracts progenitor cells to differentiate in to osteoblasts. These cells in turn produce normal bone. This unique protein was identified in late 1980s and produced commercially in late 2000s. This product was finally endorsed by authorities and launched in India. Balaji Dental and Craniofacial hospital was the first center in India to incorporate this protein for facial reconstruction in South East Asia. Dr. S. M. Balaji, performed the first such innovative surgery in the Indian Subcontinent.

Facial defects could be congenital like cleft palate or due to trauma, road traffic accidents or cancer surgeries. In this novel technology, the necessary for a bone donor site – hip bone or the rib bone is eliminated. This harvesting procedure has some potential issues besides giving an unsightly scar. The placement of rhBMP2, in the area of the defect, the material is packed. This material stimulates the dormant cells in the bone as well as attracts circulating monocytes to differentiate in to bone forming cells. Latter in 3 to 6 months time, the bone is fully formed in the defect. Prof. Michael Carstens from USA has been a pioneer in this and been to India exclusively for this launch. He briefed the trauma and pressure from cleft and how this new product offered relief. 
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