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Alveolar cleft repair using rhBMP-2 avoiding autobone graft

1/2/2016

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A 6-year-old girl was brought to our hospital by her parents for surgical correction of her cleft defect. Her cleft lip and cleft palate defect was operated elsewhere, in her childhood.
Maxillofacial Surgeon Dr. S.M. Balaji performed the alveolar cleft repair using rhBMP-2 avoiding bone grafting. Miracle protein rhBMP-2 is a bioengineered version of a protein that occurs in the body. When placed in the cleft defect, it stimulates the body’s stem cells to form new bone and thereby healing the bony defect in the teeth bearing region of the upper jaw. By using rhBMP-2, bone graft surgery from the hip or rib is avoided, thereby avoiding an additional surgery & unsightly scars.
Alveolar cleft defect
Unilateral cleft alveolus defect
3D CBCT scan showing alveolar cleft defect in left side upper jaw
Retained deciduous teeth extracted
rhBMP-2 placed in alveolar cleft avoiding bone graft
Immediately after surgery-surgical site sutured
After surgery following 3 months-3D CBCT scan showing good bone healing and complete closure of alveolar cleft defect
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Successful union of cleft bone into a single jaw bone using miracle protein rhBMP-2

12/6/2015

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​An 8 year old boy with bilateral cleft lip and palate defect from Bihar was brought to our hospital with his parents for closure of the cleft defect in the teeth bearing region of upper jaw bone and further rehabilitation of his cleft deformity. The primary cleft lip and palate repair was done elsewhere.
The premaxilla was separated from rest of the alveolus which can be clearly appreciated in 3D CBCT scan. Thus upper alveolus was separated into three different parts which will severely affect the development of teeth later.
Maxillofacial Surgeon Dr. S. M. Balaji performed the premaxillary setback procedure with rhBMP-2 which helps in uniting the three parts into a single jaw bone with new bone formation. This surgery helped for proper growth and development as well as alignment of his teeth.
Intraoperative view showing separate premaxilla due to bilateral cleft defect
3D CBCT scan showing detached and forwardly placed premaxilla from rest of the alveolus
Miracle bone protein rhBMP2 placed in the cleft region to induce new bone formation
Premaxillary segment aligned with the rest of the alveolus and stabilized
Immediately after suturing the gingivomucoperiosteal flap
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Successful premaxillary setback and complete closure of huge alveolar cleft using miracle protein rhBMP-2 in a bilateral cleft lip and palate boy

8/4/2015

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An 8-year-old boy born with bilateral cleft lip and palate reported to our hospital seeking specialized treatment for her cleft defect in the alveolar bone (teeth bearing region of upper jaw). He was previously operated for cleft lip & cleft palate elsewhere.

Due to the bilateral cleft, his maxilla or upper jaw bone was in 3 parts. Anterior segment (premaxilla) was so much forwardly placed. Maxillofacial Surgeon Dr. S.M. Balaji performed the alveolar cleft reconstruction using the miracle protein rhBMP-2 following premaxillary setback. This protein stimulates the body’s own cells to rapidly form new bone at the site of placement. Following surgery, there will be complete bone fill in the cleft defects thereby joining the 3 segments into a single complete maxilla.

By using this revolutionary technology, additional bone graft surgery and scarring at the graft site is avoided. Dr. Balaji has successfully used this novel protein in complete reconstruction of several facial bone defects.
3D CBCT scan view showing detached premaxilla due to cleft defect
During surgery complete separation of premaxilla with that of the maxilla was exposed
Following premaxillary setback alveolar cleft defect was closed with rhBMP2 bone protein
Alveolar cleft defect was corrected by placing miracle bone protein rhBMP2
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Successful reconstruction of alveolar cleft into a single jaw bone using miracle bone protein rhBMP-2

9/3/2015

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A 3 year old boy with unilateral cleft lip and palate defect from Bihar was brought to our hospital by his parents for closure of the cleft defect in the teeth bearing region of upper jaw bone. He was previously operated for cleft lip and cleft palate. Due to the cleft defect, upper alveolus was in two parts which will severely affect the development of teeth later.

Maxillofacial Surgeon Dr. S. M. Balaji performed the cleft alveolus closure with rhBMP-2 which helps in uniting the two parts into a single jaw bone with new bone formation. This surgery helped for proper growth and development as well as alignment of his teeth later.  
Preoperative intraoral view showing alveolar cleft defect in left side
Preoperative digital orthopantomogram showing cleft alveolus in left side
Intraoperative view showing alveolar cleft after raising gingivomucoperiosteal flap
rhBMP-2 placed in the alveolar cleft region to induce new bone formation
Immediately after suturing
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Alveolar cleft repair using rhBMP-2 avoiding bone graft

6/12/2014

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An 8-year-old boy was brought to our hospital by his parents for surgical correction of his cleft defect. His cleft lip and cleft palate defect was operated by Maxillofacial Surgeon Dr. S.M. Balaji, in his childhood.

Dr. Balaji performed the alveolar cleft repair using rhBMP-2 avoiding bone grafting. Miracle protein rhBMP-2 is a bioengineered version of a protein that occurs in the body. When placed in the cleft defect, it stimulates the body’s stem cells to form new bone and thereby healing the bony defect in the teeth bearing region of the upper jaw. By using rhBMP-2, bone graft surgery from the hip or rib is avoided, thereby avoiding an additional surgery & unsightly scars.
Preoperative CBCT scan image showing unilateral alveolar cleft in left side of the maxilla
Preoperative intraoral view showing cleft alveolus in the left side of the upper jaw
Gingivomucoperiosteal flap raised and alveolar cleft defect was exposed
Miracle protein rhBMP-2 was placed in the alveolar cleft defect to induce the new bone formation
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Miracle protein rhBMP-2, bone graft and implants placed to replace missing teeth in deficient jaw bone

30/9/2014

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A 45-year-old man from Australia came to our hospital seeking fixed replacement of his multiple missing teeth. The loss of many teeth over a long time led to progressive shrinkage of the jaw bone. The height of bone in the lower jaw was inadequate to place implants. Doctors elsewhere advised only removable dentures but the patient wanted fixed teeth to be able to chew and speak comfortably without the fear of dentures slipping off.

Maxillofacial Surgeon & Implantologist Dr. S.M. Balaji successfully reconstructed the deficient jaw using rhBMP-2 and bone graft to enable placement of implants and fixed teeth. The broken upper front teeth were extracted and immediate implants were placed in the same sockets without any bone loss. Implants were also placed in the right upper jaw. Implants and rhBMP-2 protein were placed in the lower jaw. This miracle protein stimulates the body’s own cells to form new bone thereby augmenting the jaw.

A costochondral rib graft was harvested & used to reconstruct the deficient height of the lower jaw and implants were placed. Subsequently, ceramic crowns closely resembling natural teeth will be fixed to the implants to complete the rehabilitation. The patient was very happy that he will have fixed teeth that will help him chew foods easily & give him a beautiful smile. 

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Combined Sphincter pharyngoplasty for speech correction and rhBMP-2 surgery for reconstruction of alveolar cleft

24/9/2014

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A 26-year-old man from Lucknow, with unilateral cleft lip and palate came to our hospital for expert cleft management. He was previously operated elsewhere for cleft lip and palate deformity. He had a nasal sounding speech and cleft in the alveolar bone (teeth-bearing jaw bone) in the right upper jaw. 

Maxillofacial Surgeon Dr. S.M. Balaji successfully performed a combined sphincter pharyngoplasty & rhBMP-2 surgery. Cleft individuals have hypernasality due to escape of air through the nose during speech. This is called velopharyngeal incompetence and is corrected by pharyngoplasty. Dr. Balaji created a dynamic sphincter by surgically rearranging the palatopharyngeus muscles.  Due to the huge alveolar cleft in the right upper jaw, the right side of his nose appeared collapsed. Dr. Balaji employed the advanced rhBMP-2 technology to completely close the bone defect. This miracle protein stimulates the body’s own cells to form new bone at the site it’s placed ultimately healing the gap. This revolutionary technology avoids a second surgery for grafting bone from the rib or hip. 
Preoperative view showing depressed nasal base in right side due to huge alveolar cleft defect
Intraoral view showing altered palatopharyngeal muscles attachment affecting speech
Palatopharyngeal muscle detached for its different position and approximated into correct position on left side
Palatopharyngeal muscle detached for its different position and approximated into correct position on right side
Huge alveolar cleft defect on right side was exposed surgically
Miracle protein rhBMP-2 was placed in the alveolar cleft defect region to induce new bone formation
The video shows the new dynamic velopharyngeal sphincter action and a positive suction test indicating successful correction of velopharyngeal incompetence.  
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Alveolar cleft repair using rhBMP-2 avoiding bone grafting

4/8/2014

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A 14-year-old boy from Sri Lanka, with unilateral cleft lip and palate, was brought to our hospital by his parents for surgical correction of alveolar cleft (cleft in the teeth-bearing bone of upper jaw). Previously he was operated for cleft lip & cleft palate elsewhere. 

Maxillofacial Surgeon Dr. S.M. Balaji performed the surgical correction of the alveolar cleft using the advanced rhBMP-2 (recombinant human Bone Morphogenetic Protein). This miracle protein stimulates the body’s own stem cells to form new bone at the site where it’s placed ultimately healing the bone defect. Following this, normal teeth eruption and teeth alignment can be achieved. The wonder of using this advanced technique is that additional surgery of bone grafting from the rib or hip is avoided and there is no scarring. 
Preoperative view showing cleft alveolus in the unilateral cleft defect in left side
During procedure cleft alveolus was surgically exposed
Miracle protein rhBMP-2 placed in the cleft alveolus defect for the cleft closure
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Successful jaw reconstruction with rhBMP-2 & complete rehabilitation with implants

12/6/2014

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A 30 year old man from Oman came to our hospital with the complaints of severe pain and swelling in the right side of his lower jaw. A 3D CT scan & thorough histopathological examination revealed he had multilocular ameloblastoma in the right lower jaw.

Maxillofacial surgeon Dr. S.M. Balaji expertly planned the complete jaw reconstruction. The affected portion of the mandible (lower jaw) was surgically ressected. A rib graft was harvested & used to reconstruct the excised portion. Miracle protein rhBMP-2 was placed. This stimulates the body’s own cells to form new bone at the site thereby ensuring complete healing of the bone defect.

Few months following surgery, remarkable healing of the jaw bone defect was seen. Implants were placed in the missing teeth region of the lower jaw and ceramic prosthesis were fixed. The man was very happy that his jaw bone defect is cured completely and with the implants he is able to chew & eat well. 
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Successful closure of alveolar cleft defect with rhBMP-2

29/5/2014

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A 6 year old boy with bilateral cleft lip and palate was brought to our hospital with the complaints of escape of food and water to the nose while eating and slurred speech due to escape of  air to the nose through the hole in the teeth bearing region of the upper jaw. Primary cleft lip and palate repair was done elsewhere.

After thorough clinical and radiographic examination Maxillofacial Surgeon Dr. S. M. Balaji diagnosed that in the previous cleft surgery the Surgeon has removed the premaxilla completely along with the developing tooth buds. Thus a part of alveolus along with the few teeth was missing which led to huge cleft defect in the midline of the upper jaw bone.  Dr. Balaji skillfully planned to close the cleft alveolar defect with the miracle protein rhBMP-2.

A gingivomucoperiosteal flap was raised and the cleft defect was exposed and miracle protein rhBMP-2 was placed in the alveolar cleft defect region and the flap was approximated with sutures. This protein helps the body’s own cells to form new bone at the site of placement. After 3 months achieving complete union of the segmented alveolar bone into a single complete maxilla, replacement of missing teeth followed by orthodontic treatment will be planned. 
Pre operative intra oral view showing missing teeth in the upper anterior region due to cleft alveolar defect
During procedure, huge alveolar cleft defect exposed due to missing premaxillary segment
Miracle protein rhBMP-2 placed in the alveolar cleft defect to induce own body cells into bone forming cells
Water tight closure of the gingivomucoperiosteal flap
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Successful union of cleft bone into a single jaw bone using miracle protein rhBMP-2

19/3/2014

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An 8 year old boy with bilateral cleft lip and palate defect from Mumbai was brought to our hospital with his parents for closure of the cleft defect in the teeth bearing region of upper jaw bone and further rehabilitation of his cleft deformity. The primary cleft lip and palate repair was done elsewhere.

The premaxilla was separated from rest of the alveolus which can be clearly appreciated in 3D CBCT scan. Thus upper alveolus was separated into three different parts which will severely affect the development of teeth later.

Maxillofacial Surgeon Dr. S. M. Balaji performed the premaxillary setback procedure with rhBMP-2 which helps in uniting the three parts into a single jaw bone with new bone formation. This surgery helped for proper growth and development as well as alignment of his teeth.
Pre operative intraoral view showing protruding premaxilla
3D CBCT scan showing detached and forwardly placed premaxilla from rest of the alveolus
Intra oral view showing severe anterior deep bite due to lowered position of premaxilla and palatally placed lateral incisors due to lack of bone
During surgery rhBMP-2 placed in the cleft defect region
Immediate post operative view showing accurate approximation of premaxilla
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Complete rehabilitation for cleft child from 3 months to 16 years of age Successive surgeries with 16 years follow-up

18/3/2014

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Sixteen years ago, a 4-month-old baby girl born with unilateral cleft lip & palate was brought to our hospital by her parents for the complete rehabilitation of her cleft deformity. Maxillofacial Surgeon Dr. S.M. Balaji performed the successive surgeries over the years.

Primary cleft lip repair surgery was done when the baby was 4 months old and palate repair surgery was done at 8 months of age. When the baby was 6 years old, rhBMP-2 surgery was done to treat the alveolar cleft defect. Miracle protein rhBMP-2 was placed in the cleft of the teeth bearing region of the upper jaw to completely heal the bony defect avoiding bone graft.

Now the girl reported to our hospital seeking to enhance her facial profile. She had a hypoplastic maxilla (retruded upper jaw) and she was not happy with her appearance. Dr. Balaji performed the intraoral maxillary distraction osteogenesis whereby the upper jaw was advanced and aligned properly with the lower jaw. This was done completely inside the mouth so there were no scars. Using distraction & orthodontics, her appearance & facial profile was greatly enhanced.  
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Alveolar cleft repair using rhBMP-2 avoiding bone graft

12/3/2014

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An 8-year-old boy was brought to our hospital by his parents for surgical correction of his cleft defect. His cleft lip and cleft palate defect was operated elsewhere, in his childhood. The surgery results were adverse as the entire pre-maxilla was removed.

Maxillofacial Surgeon Dr. S.M. Balaji performed the alveolar cleft repair using rhBMP-2 avoiding bone grafting. Miracle protein rhBMP-2 is a bioengineered version of a protein that occurs in the body. When placed in the cleft defect, it stimulates the body’s stem cells to form new bone and thereby healing the bony defect in the teeth bearing region of the upper jaw. By using rhBMP-2, bone graft surgery from the hip or rib is avoided, thereby avoiding an additional surgery & unsightly scars. 
Alveolar cleft defect
3D CBCT scan showing alveolar cleft defect in right side upper jaw
Alveolar cleft region surgically exposed
rhBMP-2 placed in alveolar cleft avoiding bone graft
rhBMP-2 stimulates new bone formation ultimately healing the bony defect
Immediately after surgery-surgical site sutured
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